基因名称：SESN1 （sestrin 1）
别名： PA26,SEST1
基因ID：27244
Chromosome(GRCh37) ：6 Start: 109307640 End: 109415708 Strand:
信号通路：
靶向药：
化疗药：
简介：这个基因编码一个sestrin家族的成员SSTRIN是由p53肿瘤抑制蛋白诱导的，并在细胞对DNA损伤和氧化应激的反应中起作用。编码蛋白通过激活amp激活的蛋白激酶介导p53对细胞生长的抑制，从而抑制雷帕霉素蛋白的哺乳动物靶点。编码过氧化过氧化还原酶的蛋白质也在抗氧化防御中起着关键作用，该基因的表达是辐射暴露的潜在标志物。另外，已经观察到该基因编码多个亚型的剪接转录变体[由RefSeq提供，2010年12月]This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
SESN1突变与药物：
