基因名称：SNAI2 （snail family transcriptional repressor 2）
别名： SLUG,WS2D,SLUGH,SLUGH1,SNAIL2
基因ID：6591
Chromosome(GRCh37) ：8 Start: 49830236 End: 49833999 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码c2h2型锌指转录因子蜗牛家族的一个成员。编码蛋白作为一种转录抑制因子，与e-box基序结合，也可能抑制乳腺癌中e-cadherin的转录。该蛋白参与上皮-间质转化，具有抗凋亡活性该基因突变可能与神经管缺陷的孢子状病例有关。[由RefSeq提供，2008年7月]This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
SNAI2突变与药物：
