基因名称：SPEN （spen family transcriptional repressor）
别名： MINT,SHARP,RBM15C,HIAA0929
基因ID：23013
Chromosome(GRCh37) ：1 Start: 16174359 End: 16266951 Strand:
信号通路： 肿瘤干细胞
靶向药：
化疗药：
简介：这个基因编码一种激素诱导的转录抑制因子。这种基因产物的转录抑制可以通过与其他抑制因子的相互作用、参与组蛋白脱乙酰化的蛋白质的募集或通过转录激活因子的分离来实现。这个基因的产物含有一个羧基末端结构域，可以与其他共加压蛋白结合。该结构域还允许与nurd复合物的成员相互作用，nurd复合物是一种核小体重塑蛋白复合物，含有脱乙酰酶活性。此外，这个阻遏物包含几个rna识别基序，这些基序与类固醇受体rna辅活化子结合；这种结合可以调节结合和非结合类固醇受体的活性。[由RefSeq提供，2008年7月]This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]
SPEN突变与药物：
