SPHK1靶向药基因

基因名称:SPHK1  (sphingosine kinase 1)

别名: SPHK
基因ID:8877
Chromosome(GRCh37) :17 Start: 74372665 End: 74383941 Strand: 1
信号通路:
靶向药:
化疗药:

简介:该基因编码的蛋白质催化鞘氨醇的磷酸化形成鞘氨醇-1-磷酸(S1P),一种具有细胞内和细胞外功能的脂质介质。在细胞内,s1p调节增殖和存活,在细胞外,它是细胞表面G蛋白偶联受体的配体。这种蛋白及其产物s1p在TNFα信号传导和在炎症、抗凋亡和免疫过程中重要的NF-kappa-b激活途径中起关键作用。另外,还发现了编码不同亚型的剪接转录变体。The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
SPHK1突变与药物:
OVEREXPRESSION
药物:
Ziv-阿柏西普 
疾病:
宫颈癌

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