基因名称：STAT2 （signal transducer and activator of transcription 2）
别名： P113,IMD44,ISGF-3,STAT113
基因ID：6773
Chromosome(GRCh37) ：12 Start: 56735381 End: 56754058 Strand:
信号通路：
靶向药：
化疗药：
简介：这个基因编码的蛋白质是stat蛋白家族的一员。在对细胞因子和生长因子的反应中，stat家族成员被受体相关的激酶磷酸化，然后形成homo-或异二聚体，在那里它们作为转录激活因子转移到细胞核。作为对干扰素（ifn）的反应，该蛋白与stat1和ifn调节因子家族蛋白p48（isgf3g）形成复合物，在该复合物中，该蛋白充当反式激活因子，但缺乏直接结合dna的能力。转录接合器p300/cbp（ep300/crebbp）与该蛋白特异性相互作用，被认为参与了腺病毒阻断ifn-α反应的过程。已发现该基因编码不同亚型的多个转录变体。[由RefSeq提供，2010年3月]The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
STAT2突变与药物：
