STAT4靶向药基因

基因名称:STAT4  (signal transducer and activator of transcription 4)

别名: SLEB11
基因ID:6775
Chromosome(GRCh37) :2 Start: 191894302 End: 192037404 Strand:
信号通路: 炎症相关
靶向药:
化疗药:

简介:这个基因编码的蛋白质是转录因子stat家族的一员。在对细胞因子和生长因子的反应中,stat家族成员被受体相关的激酶磷酸化,然后形成homo-或异二聚体,在那里它们作为转录激活因子转移到细胞核。这种蛋白对于调节淋巴细胞对il12的反应和调节t辅助细胞的分化至关重要。该基因突变可能与系统性红斑狼疮和类风湿关节炎有关。交替剪接导致编码相同蛋白质的多个转录变体。[由RefSeq提供,2011年8月]The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
STAT4突变与药物:

常见问题
  • 如何在体龙基因完成所需的检测项目 流程简述 :在线咨询 - 采样送检 - 付款检测 - 检测分析 - 报告结果
查看详情

相关内容

官方客服团队

为您解决烦忧 - 24小时在线 专业服务