基因名称：STAT6 （signal transducer and activator of transcription 6）
别名： STAT6B,STAT6C,D12S1644,IL-4-STAT
基因ID：6778
Chromosome(GRCh37) ：12 Start: 57489187 End: 57505196 Strand:
信号通路：
靶向药：
化疗药：
简介：这个基因编码的蛋白质是转录因子stat家族的一员。在对细胞因子和生长因子的反应中，stat家族成员被受体相关的激酶磷酸化，然后形成homo-或异二聚体，在那里它们作为转录激活因子转移到细胞核。这种蛋白在发挥IL4介导的生物学反应中起着中心作用结果表明，IL4可诱导BCL2L1/BCL-X（L）的表达，而BCL2L1/BCL-X（L）的表达与IL4的抗凋亡活性有关小鼠的基因敲除研究表明，该基因在t辅助细胞2（th2）分化、细胞表面标志物表达和免疫球蛋白类转换中的作用。选择性剪接导致多个转录变体。[由RefSeq提供，2010年5月]The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
STAT6突变与药物：
