基因名称:STK24 (serine/threonine kinase 24)
别名: MST3,STK3,MST3B,STE20,HEL-S-95
基因ID:8428
Chromosome(GRCh37) :13 Start: 99102455 End: 99229396 Strand:
信号通路:
靶向药:
化疗药:
简介:该基因编码丝氨酸/苏氨酸蛋白激酶,在丝裂原活化蛋白激酶(MAPK)信号传导的上游起作用编码的蛋白质被caspases切割成两条链;n末端片段(mst3/n)转移到细胞核并促进细胞程序性死亡。在x染色体上有一个假基因。选择性剪接导致多个转录变异。[ RefSeq,2013月11日]This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
STK24突变与药物: