基因名称：TBX3 （T-box transcription factor 3）
别名： UMS,XHL,TBX3-ISO
基因ID：6926
Chromosome(GRCh37) ：12 Start: 115108059 End: 115121969 Strand:
信号通路： 肿瘤干细胞
靶向药：
化疗药：
简介：这个基因是一个系统学保守的基因家族的成员，该家族共享一个共同的dna结合域t-box。t-box基因编码参与发育过程调控的转录因子。这种蛋白是一种转录抑制因子，被认为在四足动物前肢的前/后轴起作用。该基因突变导致尺乳综合征，影响肢体、大汗腺、牙齿、头发和生殖器发育。该基因的选择性剪接导致三个转录变体编码不同的亚型；然而，一个变体的全长性质尚未确定。[由RefSeq提供，2008年7月]This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
TBX3突变与药物：
