基因名称:TCF7L2 (transcription factor 7 like 2)
别名: TCF4,TCF-4
基因ID:6934
Chromosome(GRCh37) :10 Start: 114709978 End: 114927437 Strand:
信号通路:
靶向药:
化疗药:
简介:该基因编码一个高迁移率族(hmg)盒,包含在wnt信号通路中起关键作用的转录因子。这种蛋白质与血糖稳态有关。这种基因的遗传变异与2型糖尿病风险增加有关。已经发现了该基因编码多种不同亚型的转录变体。[由RefSeq提供,2010年10月]This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
TCF7L2突变与药物: