TET2靶向药基因

基因名称:TET2  (tet methylcytosine dioxygenase 2)

别名: KIAA1546,MDS
基因ID:54790
Chromosome(GRCh37) :4 Start: 106067032 End: 106200973 Strand: 1
信号通路: 能量代谢
靶向药:
化疗药:

简介:该基因编码的蛋白是一种催化甲基胞嘧啶转化为5-羟甲基胞嘧啶的甲基胞嘧啶双加氧酶。编码蛋白参与骨髓生成,该基因的缺陷与数种骨髓增生性疾病有关。该基因有两个编码不同亚型的变体。The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
TET2突变与药物:

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