基因名称：TLK2 （tousled like kinase 2）
别名： HsHPK,PKU-ALPHA
基因ID：11011
Chromosome(GRCh37) ：17 Start: 60536019 End: 60692842 Strand: 1
信号通路：
靶向药： GF109203X Go6983
化疗药：
简介：这个基因编码一个核丝氨酸/苏氨酸激酶，最初在拟南芥中被鉴定出来。编码蛋白被认为通过调节组蛋白H3/H4伴侣蛋白的水平来调节细胞周期S期染色质的装配。这种蛋白与辐射引起的DNA损伤的双链断裂修复有关。该基因的假基因存在于染色体10和17上。交替剪接导致多个转录变体。This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants.
TLK2突变与药物：
AMPLIFICATION
药物：
GF109203X Go6983
疾病：
乳腺癌
