基因名称：TNFAIP3 （TNF alpha induced protein 3）
别名： A20,AISBL,OTUD7C,TNFA1P2
基因ID：7128
Chromosome(GRCh37) ：6 Start: 138188325 End: 138204451 Strand:
信号通路： 免疫相关
靶向药：
化疗药：
简介：该基因被鉴定为一种能被肿瘤坏死因子（TNF）快速诱导表达的基因。该基因编码的蛋白是锌指蛋白和ubiqitin编辑酶，具有抑制nf-kappa b激活和肿瘤坏死因子介导的细胞凋亡的作用。编码的蛋白具有泛素连接酶和氘蛋白酶活性，参与细胞因子介导的免疫和炎症反应。已经发现了一些编码相同蛋白质的转录变体。[由RefSeq提供，2012年7月]This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
TNFAIP3突变与药物：
