基因名称:TNFRSF14 (TNF receptor superfamily member 14)
别名: TR2,ATAR,HVEA,HVEM,CD270,LIGHTR
基因ID:8764
Chromosome(GRCh37) :1 Start: 2487291 End: 2495268 Strand:
信号通路: 细胞增殖
凋亡抑制
靶向药:
化疗药:
简介:这个基因编码肿瘤坏死因子受体超家族的一个成员。编码蛋白在激活炎症和抑制t细胞免疫反应的信号转导途径中发挥作用。它与单纯疱疹病毒(hsv)包膜糖蛋白d(gd)结合,介导其进入细胞。选择性剪接导致多个转录变体。[由RefSeq提供,2014年7月]This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
TNFRSF14突变与药物: