TOP3A靶向药基因

基因名称:TOP3A  (DNA topoisomerase III alpha)

别名: TOP3,PEOB5,ZGRF7,MGRISCE2
基因ID:7156
Chromosome(GRCh37) :17 Start: 18177235 End: 18218321 Strand:
信号通路:
靶向药:
化疗药:

简介:这个基因编码一种dna拓扑异构酶,一种在转录过程中控制和改变dna拓扑异构酶状态的酶。这种酶能催化单链dna的瞬时断裂和重新连接,从而使单链dna彼此穿过,从而减少超螺旋的数量并改变dna的拓扑结构。这种酶与blm形成复合物,在体细胞重组中起调节作用。选择性剪接导致编码不同亚型的多个转录变体。[由RefSeq提供,2016年3月]This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
TOP3A突变与药物:

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