基因名称:TRAF7 (TNF receptor associated factor 7)
别名: RFWD1,RNF119,CAFDADD
基因ID:84231
Chromosome(GRCh37) :16 Start: 2205763 End: 2228130 Strand:
信号通路:
靶向药:
化疗药:
简介:肿瘤坏死因子(TNF;见MIM 191160)受体相关因子,如TRAF7,是TNF受体超家族成员的信号转导因子(见MIM 191190)。trafs由一个富含n-末端半胱氨酸/组氨酸的区域组成,该区域含有锌环和/或锌指基序;一个卷曲的线圈(亮氨酸拉链)基序;以及一个定义traf家族的同源区域,traf域,其参与自缔合和受体结合。[由omim提供,2004年4月]Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
TRAF7突变与药物: