基因名称：TSHR （thyroid stimulating hormone receptor）
别名： LGR3,CHNG1,hTSHR-I
基因ID：7253
Chromosome(GRCh37) ：14 Start: 81421333 End: 81612646 Strand:
信号通路： 细胞增殖
靶向药：
化疗药：
简介：该基因编码的蛋白是一种膜蛋白，是甲状腺细胞代谢的主要调控因子。编码蛋白是甲状腺素和甲状腺素的受体，其活性由腺苷酸环化酶介导。这个基因的缺陷是几种甲状腺机能亢进症的原因。已经发现了三个编码不同亚型的转录变体。[由RefSeq提供，2008年12月]The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
TSHR突变与药物：
