UBR5靶向药基因

基因名称:UBR5  (ubiquitin protein ligase E3 component n-recognin 5)

别名: DD5,EDD,HYD,EDD1
基因ID:51366
Chromosome(GRCh37) :8 Start: 103264501 End: 103424947 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因编码孕激素诱导蛋白,属于HECT(与E6-AP羧基末端同源)家族hect家族蛋白作为e3泛素蛋白连接酶发挥作用,靶向泛素介导的蛋白水解的特异性蛋白。该基因定位于染色体8q22,在多种癌症中被破坏。这个基因可能在细胞增殖或分化的调节中起作用[由RefSeq提供,2008年7月]This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
UBR5突变与药物:

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