WDR5靶向药基因

基因名称:WDR5  (WD repeat domain 5)

别名: SWD3,BIG-3,CFAP89
基因ID:11091
Chromosome(GRCh37) :9 Start: 137000801 End: 137025094 Strand:
信号通路:
靶向药:
化疗药:

简介:这个基因编码WD重复蛋白家族的一个成员。WD重复是大约40个氨基酸的最小保守区域,通常由GLY HIT和Trp ASP(GH-WD)包围,这可能促进异源三聚体或多蛋白复合物的形成。该家族成员参与多种细胞过程,包括细胞周期进程、信号转导、凋亡和基因调控这种蛋白质含有7个WD重复序列。另外,编码相同蛋白质的剪接转录变体已经被鉴定。[由RefSeq提供,2008年7月]This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
WDR5突变与药物:

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