基因名称：WEE1 （WEE1 G2 checkpoint kinase）
别名： WEE1A,WEE1hu
基因ID：7465
Chromosome(GRCh37) ：11 Start: 9595228 End: 9615004 Strand: 1
信号通路： 细胞增殖
靶向药： AZD1775
PLATINUM
化疗药：吉西他滨
简介：该基因编码一种核蛋白，这是一种属于SER/THR蛋白激酶家族的酪氨酸激酶。这种蛋白催化CDC2/cyclin B激酶的抑制性酪氨酸磷酸化，并似乎通过保护细胞核免受细胞质激活的CDC2激酶的影响来协调DNA复制和有丝分裂之间的转换。This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.
WEE1突变与药物：
OVEREXPRESSION
药物：
AZD1775
疾病：
弥漫性固有桥脑胶质瘤
RS3910384
药物：
吉西他滨 PLATINUM 疾病：
“非小细胞肺癌”
