基因名称：YAP1 （Yes associated protein 1）
别名： COB1,YAP,YAP2,YAP65,YKI
基因ID：10413
Chromosome(GRCh37) ：11 Start: 101981192 End: 102104154 Strand: 1
信号通路：
靶向药：
化疗药：氟尿嘧啶 多西他赛 维替泊芬
简介：这个基因编码河马信号通路的下游核效应器，它参与发育、生长、修复和体内平衡。已知该基因在多种癌症的发展和进展中发挥作用，作为该信号通路的转录调节因子，并可能作为癌症治疗的潜在靶点发挥作用。选择性剪接导致编码不同亚型的多个转录变体。This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.
YAP1突变与药物：
OVEREXPRESSION
药物：
5-FU 多西他赛 维替泊芬 疾病：
食管癌
