基因名称:ZBTB16 (zinc finger and BTB domain containing 16)
别名: PLZF,ZNF145
基因ID:7704
Chromosome(GRCh37) :11 Start: 113930289 End: 114126702 Strand:
信号通路:
靶向药:
化疗药:
简介:该基因是krueppel c2h2型锌指蛋白家族的成员,编码一个锌指转录因子,在羧基末端包含九个kruppel型锌指结构域。该蛋白位于细胞核内,参与细胞周期进程,并与组蛋白脱乙酰酶相互作用。该位点基因重排异常的特殊情况与急性早幼粒细胞白血病(apl)有关。交替转录剪接变体已经被描述[由RefSeq提供,2008年7月]This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
ZBTB16突变与药物: